Current Problems of Psychiatry

Current Problems of Psychiatry

Analysis of apoptosis via reticular pathway (caspase 12) in L-arginine induced cell death in rats’ hepatocytes


Curr Probl Psychiatry 2011; 12(4): 587-589

Agnieszka Pedrycz1, Piotr Siermontowski2, Piotr Baran3, Marcin Orłowski4

1 Department of Histology and Embryology Medical University in Lublin
2 Department of Maritime & Hyperbaric Medicine, Military Institute of Medicine, Gdynia
3 Ward of Gyneacology, Independent Public Health Care in Garwolin
4 Centrum of Diagnosis and Therapy of Digestive System’s Diseases Gdańsk


The aim of present study was assessment of reticular pathway of nitric oxide induced programmed cell death. In intrinsic pathway if apoptosis the mitochondria or endoplasmic reticulum are involved. This is the result of cellular stress and destruction endoplasmic membranes in the cell. In experiment we used rats divided into two groups. Animals from experimental group received L-arginine -precursor of nitric oxide. Specimens taken from liver of decapitated rats was prepared to immunohistochemical method detected caspase 12. Caspase 12 is the enzyme in endoplasmic reticulum. We used standard three step method. In the slides of the liver of rats from experi-mental and control group we didn’t detect overexpression of caspase 12.


liver, caspase 12, programmed cell death, NO


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